Gut Health 101

Why is gut health important ?

Gut hosts 70% of your immune cells, 500 million neurons, 100% of your body fuel and your microbiome.

Gut health covers multiple positive aspects, such as the effective digestion and absorption of food, the absence of illness, normal and stable microbiota, effective immune status and a state of well-being. There is a delicate interaction between you and your microbiota. The disruption of this balance has a direct effect on your health and ageing, not just in your gut but in your whole body, for example your skin or the brain.

Gut health maintanace involves continues interaction between your microbiota, your immune system and the intact barrier between them.

What includes the Gut microbiota?

A community of slightly over 38 trillion (12 zeroes!) microorganisms is a part of us, primarily bacteria, living in and on our bodies. The majority reside in the gastrointestinal tract, but many others live in diverse places like your mouth, skin, and armpits. They represent more than 50% of you by cell count. 

Collectively, the genes harbored in these trillions of microbial cells constitute your microbiome.

Isnt bacteria harmful?

Of all the bacteria that interact with our body, we now know less than 100 pose a pathogenic threat to humans. Most are harmless (commensal). Many are beneficial (mutualistic). The ones that live in and on us are essential.

How does the Microbiome contribute to Immune fitness?

It is generally regarded to start at birth. Eventually, breast milk and the surrounding environment—other moms, dads, siblings, dogs, the ground, nature—contributes to this microbial biodiversity.

These first microbes colonize your gastrointestinal system and form the foundation of your immune system, serving as the instructors of what is dangerous and what is not. Bifidobacteria are essential for this. By the first few years of life, the microbiota stabilises into the steady-state, resembling more or less what you have today.

What does immune system do?

A huge proportion (70%) of your immune system is in your gut. Your immune system is inside your body and bacteria are outside your body, yet they interact through a constant communication and exchange.

Your immune system both controls your gut microbiota and it depends on it for a normal function and development of your body. Your protection and maintenance of gut health is dependent on the ability of your immune system to regulate the complex balance between the defence against and the acceptance of the gut microbiota.

How does Gut Microbiota communicate with the immune system?

The interplay between our gut microbiota and our immune system development and function includes continuous interactions in both health and disease.

The microbiome plays critical roles in the training and development of major components of our immune system, while the immune system orchestrates the maintenance of key features of host-microbe symbiosis, mainly through its barrier function that is more than just a mechanical barricade and contributes to gut immune responses that play a key role in regulating gut health.

In one way, a functional gut barrier can regulate the diversity of bacterial species, counteracting harmful bacteria and cooperating with beneficial ones; and in reverse, the
microbiota can alter the gut barrier integrity by modulating the innate (inherited) immune system. Imbalances in those microbiota-immunity interactions under defined environmental contexts are believed to contribute to the pathogenesis of a multitude of immune-mediated disorders.

In short, gut barrier and gut microbiota are two crucial factors affecting gut health.

Over the last 20 years, the focus has been on the microbiota arm of this interaction. The communication between your microbiota and the immune system happens through generation of active ingredients (signalling molecules) by microbiota. Depending on their chemical structures they can carry postive or negative information. Y Skin contains active ingredients that focus on the barrier function to complement the microbiome modulators and/or the intestinal immune responses.